basic FUNCTION
| playing an important role in growth control associated with terminal differentiation and cellular senescence |
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may play a significant role in regulating cellular growth and overlapping gene expression changes, also induced by IFN, may contribute to these important physiological processes |
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predominantly mitochondrial protein, and via its localization in both mitochondria and cytoplasm, is able to target a specific cytoplasmic mRNA, MYC, for degradation and through this process induce cellular senescence |
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plays an essential role in mediating IFN-mediated growth inhibition and its upregulation might mediate chronic inflammatory pathological processes during aging  |
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type I IFN-inducible 3,5 prime exoribonuclease that mediates mRNA degradation |
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involved in RNA polyadenylation, degradation, and processing in prokaryotes and organelles  |
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although located in the intermembrane space, is potentially involved, most likely by indirect means, in the processing and polyadenylation of mtRNA  |
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could be involved in RNA targeting to human mitochondria |
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new role for PNPASE in regulating the import of nuclear-encoded RNAs into the mitochondrial matrix  |
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has a central role in augmenting the import of small RNA components required for DNA replication and RNA processing into the mitochondrial matrix  |
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represents the first receptor-like component that binds RNA in mammalian cells to mediate RNA import into the mitochondrial matrix |
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crucial role in mitochondrial import of small RNAs needed for replication, transcription, and translation of the mitochondrial genome |
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RNA-processing enzyme with expanding roles in regulating cellular physiology  |
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involved in mitochondrial translation and RNA import  |