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FLASH GENE
Symbol FGF3 contributors: mct/np - updated : 15-09-2012
HGNC name fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
HGNC id 3681
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic signal peptide
  • a bipartite nuclear localization signal
  • a interleukin 1/heparin-binding growth factor motif
  • a S2 binding domains important for both NOBP and RPS2 interaction
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Fgf31
    ortholog to rattus fgf3
    homolog to chicken fgf3
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF7 subfamily
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • may be involved in ear development
  • nuclear form inhibits cell proliferation by interfering with ribosomal biogenesis
  • required for dorsal patterning and morphogenesis of the inner ear epithelium
  • FGF3 and FGF10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination
  • FGF10 and FGF3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HNF1B, acts directly through FGF3, and promotes caudal hindbrain identity by activating MAFB and EGR2 via the RAS-ERK1/2 intracellular pathway
  • key role for FGF3, and a secondary role for FGF10, in WNT8A expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDMM , DUP11QP , OTDD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in esophageal squamous cell carcinoma, breast, head, and neck and lung carcinomas
    Susceptibility to nonsyndromic cleft lip and palate
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS