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FLASH GENE

Symbol

FGF3

contributors: mct/np - updated : 15-09-2012

HGNC name	fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
HGNC id	3681

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.45 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see PYGM PYGM

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005247 3 - 1548 NP_005238 26.8 239 - Riley (07)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	during embryonic development of inner ear and tooth

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an hydrophobic signal peptide
	a bipartite nuclear localization signal
	a interleukin 1/heparin-binding growth factor motif
	a S2 binding domains important for both NOBP and RPS2 interaction

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Fgf31
	ortholog to rattus fgf3
	homolog to chicken fgf3

Homologene

FAMILY	heparin-binding growth factors family
	FGF7 subfamily

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION	may be involved in ear development
	nuclear form inhibits cell proliferation by interfering with ribosomal biogenesis
	required for dorsal patterning and morphogenesis of the inner ear epithelium
	FGF3 and FGF10 are not required for specification of cardiovascular progenitors, but rather for their normal developmental coordination
	FGF10 and FGF3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	HNF1B, acts directly through FGF3, and promotes caudal hindbrain identity by activating MAFB and EGR2 via the RAS-ERK1/2 intracellular pathway
	key role for FGF3, and a secondary role for FGF10, in WNT8A expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDMM , DUP11QP , OTDD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in esophageal squamous cell carcinoma, breast, head, and neck and lung carcinomas

Susceptibility

to nonsyndromic cleft lip and palate

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS