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FLASH GENE
Symbol CCPG1 contributors: mct - updated : 22/10/2008
HGNC name cell cycle progression 1
HGNC id 24227
Location 15q21.1      Physical location : 55.647.437 - 55.700.574
Synonym name
  • cell cycle progression, restoration 8 homolog
  • cell cycle progression 8 protein
  • Synonym symbol(s) KIAA1254, CPR8
    DNA
    TYPE functioning gene
    STRUCTURE 53.13 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 6698 - 757 - Edwards (1997)
    8 - 6666 - 757 - Edwards (1997)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • MCF2L binding domain not sufficient to suppress MCF2L exchange activity on RhoA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY storage
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • scaffold protein, mediating recruitment of endogenous Src kinase into MCF2L-containing complexes and interacts with the Rho family member Cdc42
  • regulatory scaffold protein that can function as both an assembly platform for Rho protein signaling complexes and a regulatory protein which can restrict the substrate utilization of a promiscuous RhoGEF family member
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with MCF2L and modulates its exchange specificity
    (binds to the Dbl homology/pleckstrin homology domain tandem motif of MCF2L and inhibits its exchange activity toward RhoA, but not Cdc42)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS