basic FUNCTION
| normal function may be in spermatogenesis and in the development of the central nervous system |
|
involved in early development of a large domain of the central nervous system encompassing much of the midbrain and rostral metencephalon |
|
instructs early eural crest stem cells to adopt a sensory neuronal fate in a beta-catenin-dependent manner |
|
role in patterning of the midbrain region and specifying dopaminergic progenitors or regulating survival |
|
implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis |
|
role in the induction of the mesencephalon and cerebellum |
|
early requirement of WNT1 for all midbrain dopamine (MbDA) neurons |
|
plays a crucial role in bone formation and bone-remodeling processes |
|
in the bone compartment, WNT1 influences the osteoblast lineage itself or some adjacent cell type |
|
involvement of WNT1 and FZD1 in the pathogenesis and development of ALS |
|
HIF1A-dependent induction of WNT1 in hypoxic macrophages undermines autophagy in epithelial cells |
|
importance of palmitoylation for WNT1 activity and PORCN is an O-acyl transferase for WNT1 |
|
WNT1 stimulates osteogenic differentiation and mineralization of human periodontal ligament fibroblasts (hPLFs), mainly by activating the canonical WNT/CTNNB1 pathway, in which RUNX2 is a key downstream regulator |
|
during macrophage differentiation from monocytes, WNT1 promotes CD36 expression via activation of PPARG and TCF4 |