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FLASH GENE
Symbol INS contributors: mct/npt/shn - updated : 16-10-2010
HGNC name insulin
HGNC id 6081
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B-chain
  • a connecting C-peptide
  • an A-chain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ins2
    ortholog to ins, Danio rerio
    ortholog to INS, Pan troglodytes
    Homologene
    FAMILY
  • insulin family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism (Jirácek 2010)
  • increasing cell permeability to monosaccharides, amino-acids, fatty acids
  • regulating the activity of ERK5
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • two peptides A and B covalently linked via two disulfide bounds
    • INTERACTION
    DNA
  • SYT8 gene (
    • RNA
    small molecule
    protein
  • granuphilin (
  • leptin (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MODY10 , PNDM4
    Susceptibility to childhood obesity
    Variant & Polymorphism repeat VNTR increasing the risk of childhood obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS