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FLASH GENE
Symbol EPB41L5 contributors: mct/npt/pgu - updated : 16-02-2010
HGNC name erythrocyte membrane protein band 4.1 like 5
HGNC id 19819
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FERM domain, involved in binding to the HOOK domain of MPP5, a previously identified interactor of Crumbs
  • one band 4.1 like domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the mammalian CRB-MPP5 polarity complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the intracellular domains of all three Crumbs homologs through its FERM domain
  • binds to paxillin through its C terminus, enhancing integrin/paxillin association, thereby stimulating focal adhesion formation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS