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FLASH GENE

Symbol

EPB41L5

contributors: mct/npt/pgu - updated : 16-02-2010

HGNC name	erythrocyte membrane protein band 4.1 like 5
HGNC id	19819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	166.03 kb     25 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020909 25 - 6567 NP_065960 81.7 733 - 2007 17920587

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta     highly Endocrine pancreas         Nervous brain           spinal cord       highly Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal     Nervous central

cell lineage
cell lines	pancreatic cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one FERM domain, involved in binding to the HOOK domain of MPP5, a previously identified interactor of Crumbs
	one band 4.1 like domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION

functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

member of the mammalian CRB-MPP5 polarity complex

INTERACTION

DNA

RNA

small molecule

protein	associates with the intracellular domains of all three Crumbs homologs through its FERM domain
	binds to paxillin through its C terminus, enhancing integrin/paxillin association, thereby stimulating focal adhesion formation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS