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FLASH GENE

Symbol

EPB41L4B

contributors: mct - updated : 31-10-2015

HGNC name	erythrocyte membrane protein band 4.1 like 4B
HGNC id	19818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one FERM domain (325 AA) controlling cytoskeletal function in differentiating cells

HOMOLOGY

interspecies	homolog to murine Epb41l4b
	homolog to Drosophila melanogaster Yurt

intraspecies

homolog to NBL4

Homologene

FAMILY

NF2/ERM/4.1 superfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytoskeleton
text	localized along apical cell-cell boundaries

basic FUNCTION

may promote the invasive ability of breast cancer cells via regulation of matrix metalloproteinase 9 (MMP9)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with and activates ARHGEF18, a Rho-specific guanine nucleotide exchanging factor (GEF), at apical cell-cell junctions
	CRB3-dependent changes in endocytic trafficking were also dependent on EPB41L4B

cell & other

REGULATION

Other

regulated by androgens

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   were correlated with breast cancer progression, metastasis, and poor prognosis (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS