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FLASH GENE
Symbol PKNOX2 contributors: - updated : 20-06-2006
HGNC name PBX/knotted 1 homeobox 2
HGNC id 16714
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
intraspecies homolog to PREP1
Homologene
FAMILY
  • TALE (three amino acid loop extension) class of homeodomain-containing transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text colocalizes with both the actin and microtubule cytoskeletons
    basic FUNCTION
  • playing a role in tissue -specific regulation of transcription
  • transcriptional regulator (action modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer with PBX1
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with PBX in apparently non-HOX-dependent cooperative DNA binding as well
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS