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FLASH GENE

Symbol

PKNOX2

contributors: - updated : 20-06-2006

HGNC name	PBX/knotted 1 homeobox 2
HGNC id	16714

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Nervous brain       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

intraspecies

homolog to PREP1

Homologene

FAMILY

TALE (three amino acid loop extension) class of homeodomain-containing transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	colocalizes with both the actin and microtubule cytoskeletons

basic FUNCTION	playing a role in tissue -specific regulation of transcription
	transcriptional regulator (action modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer with PBX1

INTERACTION

DNA

RNA

small molecule

protein

interact with PBX in apparently non-HOX-dependent cooperative DNA binding as well

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS