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FLASH GENE
Symbol PKNOX2 contributors: - updated : 20-06-2006
HGNC name PBX/knotted 1 homeobox 2
HGNC id 16714
Location 11q24      Physical location : 125.034.558 - 125.303.283
Synonym symbol(s) PREP2, FLJ13074
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 81.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousbrain   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
intraspecies homolog to PREP1
Homologene
FAMILY
  • TALE (three amino acid loop extension) class of homeodomain-containing transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text colocalizes with both the actin and microtubule cytoskeletons
    basic FUNCTION
  • playing a role in tissue -specific regulation of transcription
  • transcriptional regulator (action modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer with PBX1
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with PBX in apparently non-HOX-dependent cooperative DNA binding as well
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS