Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CDCP1

contributors: mct - updated : 23-08-2012

HGNC name	CUB domain containing protein 1
HGNC id	24357

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon and lung cancer tumoral     --over   in pancreatic cancer, significantly correlated with overall survival tumoral     --over   in highly metastatic melanomas tumoral     --over   can be correlated with low overall patient survival in kidney cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for metastatic cancers, especially clear cell renal cell carcinoma
Therapy target
	System Type Disorder Pubmed cancer urinary   might serve as a therapeutic target for clear cell renal cell carcinoma cancer endocrine pancreas molecules blocking the expression, phosphorylation, or the PRKCD-binding site of CDCP1 are potential therapeutic candidates for pancreatic cancer cancer lung   novel target for treating cancer-specific disorders, such as metastasis, by regulating anoikis in lung adenocarcinoma cancer     targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway cancer metastases   potential therapeutic target for metastatic cancers

ANIMAL & CELL MODELS