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FLASH GENE

Symbol

CDCP1

contributors: mct - updated : 23-08-2012

HGNC name	CUB domain containing protein 1
HGNC id	24357

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.31      Physical location : 45.123.769 - 45.187.914
Synonym name	transmembrane and associated with src kinases
Synonym symbol(s)	CD318, TRASK, SIMA135, UNQ2486/PRO5773, gp140

DNA

TYPE	functioning gene
STRUCTURE	64.15 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box) (TATA box)
	cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022842 9 - 6017 92 836 - 2011 21220330 NM_178181 4 splicing 1410 37 343 - 2011 21220330 differs in the 3' UTR has a distinct and shorter C-terminus

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       stomach         Reproductive male system prostate       Urinary bladder

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three extracellular CUB domains

HOMOLOGY

interspecies

ortholog to murine Cdcp1

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	likely involved in cell adhesion or interacting with the extracellular matrix
	functions as an antiapoptotic molecule and indicate that during metastasis CDCP1 facilitates tumor cell survival likely during or soon after extravasation
	regulates anoikis resistance as well as cancer cell migration and invasion
	CDCP1 expression might play a crucial role in poor outcome of pancreatic cancer through promotion of invasion and metastasis
	having functions to regulate cell adhesion
	is not only a surface marker for cells with higher metastatic potential, but also functionally involved in enhancing tumor metastasis
	key requirement for CDCP1-mediated activation of SRC (and perhaps other SFKs) in the functions of CDCP1 in altered cell–cell and cell–substratum adhesion and in metastasis
	CDCP1 expression might play a crucial role in poor outcome of clear cell renal cell carcinoma patients through stimulation of migration and metastasis
	hypoxia-inducible and VHL-regulated gene
	plays a critical role in the process of metastasis and in the survival of cells at distant sites of metastasis
	SRC-associated protein CDCP1 regulates adhesion and motility

CELLULAR PROCESS	cell life
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hypoxia activates a CDCP1-SRC signaling pathway that appears to play a critical role in migration under hypoxic conditions

a component

INTERACTION

DNA

RNA

small molecule

protein	modulates the enzymatic activity of PRKCD through the tyrosine phosphorylation of PRKCD by recruiting PRKCD to SRC family kinases
	specifically regulates phosphorylation of PRKCD, but not of focal adhesion kinase or Crk-associated substrate
	downstream target of HIFs and plays a critical role in kidney cancer migration
	SRC substrate potentially involved in metastasis
	is a key regulator of EGF/EGFR-induced cell migration
	critical role for CDCP1 as a unique EPAS1 target gene involved in the regulation of cancer metastasis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colon and lung cancer tumoral     --over   in pancreatic cancer, significantly correlated with overall survival tumoral     --over   in highly metastatic melanomas tumoral     --over   can be correlated with low overall patient survival in kidney cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for metastatic cancers, especially clear cell renal cell carcinoma
Therapy target
	System Type Disorder Pubmed cancer urinary   might serve as a therapeutic target for clear cell renal cell carcinoma cancer endocrine pancreas molecules blocking the expression, phosphorylation, or the PRKCD-binding site of CDCP1 are potential therapeutic candidates for pancreatic cancer cancer lung   novel target for treating cancer-specific disorders, such as metastasis, by regulating anoikis in lung adenocarcinoma cancer     targeting of CDCP1 may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway cancer metastases   potential therapeutic target for metastatic cancers

ANIMAL & CELL MODELS