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FLASH GENE
Symbol IL22RA2 contributors: mct - updated : 09-04-2019
HGNC name interleukin 22 receptor, alpha 2
HGNC id 14901
Location 6q23.3      Physical location : 137.464.957 - 137.494.785
Synonym name
  • cytokine receptor class-II member 10
  • cytokine receptor family type 2, soluble 1
  • interleukin 22-binding protein
  • Synonym symbol(s) MGC150509, MGC150510, IL-22BP, CRF2-S1, CRF2X, CRF2-10, IL-22R-alpha-2, IL-22RA2, ZCYTOR16
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text head-to--tail orientation with IFNGR1
    STRUCTURE 29.83 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MYB 6q23.3-q24 v-myb myeloblastosis viral oncogene homolog (avian) AHI1 6q23.2 Abelson helper integration site LOC391973 6 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) PDE7B 6q23-q24 phosphodiesterase 7B DUFD1 6q23.2 DUF729 domain containing 1 BTF 6q23 DUF729 domain containing 1 MAP7 6q23.3 microtubule-associated protein 7 MAP3K5 6q22.33 mitogen-activated protein kinase kinase kinase 5 PEX7 6q21-q22.2 peroxisomal biogenesis factor 7 SLC35D3 6q23.2 solute carrier family 35, member D3 IL20RA 6q23.3 interleukin 20 receptor, alpha IL22RA2 6q24-q25.1 interleukin 22 receptor, alpha 2 IFNGR1 6q23-q24 interferon gamma receptor 1 OLIG3 6q23.3 oligodendrocyte transcription factor 3 LOC391974 6 similar to RIKEN cDNA 5730434I03 gene LOC134897 6q23.3 similar to protein tyrosine phosphatase TNFAIP3 6q23-q25 tumor necrosis factor, alpha-induced protein 3 PERP 6q24 PERP, TP53 apoptosis effector PBOV1 6q23-q24 prostate and breast cancer overexpressed 1 KIAA1244 6q23.3 KIAA1244 HEBP2 6q24 heme binding protein 2 KIAA1357 6q23.3 KIAA1357 protein LOC389430 6 LOC389430 C6orf80 6q23.1-q24.1 chromosome 6 open reading frame 80 CCRL1P 6q23.3 chemokine (C-C motif) receptor-like 1 pseudogene LOC345930 6q23.3 similar to Ect2 protein REPS1 6q23.1-24.1 RALBP1 associated Eps domain containing 1 C6orf115 6q24.1 chromosome 6 open reading frame 115
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2910 - 263 - 2016 27678220
  • variant 1, IL22BPi1
  • capable of neutralizing the biological activity of IL22
  • 6 - 2814 - 231 - 2016 27678220
  • IL22BPi2
  • lacking a segment within the coding region leading to a frameshift
  • capable of neutralizing the biological activity of IL22
  • 5 - 2644 - 130 is largely retained in the endoplasmic reticulum (ER) 2016 27678220
  • variant 3, IL22BPi3
  • lacking two fragments in the coding region, leadind to a frameshift aénd a shurter isoform
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
    Reproductivefemale systembreast   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one signal peptide
  • four cysteine conserved among members of the class II cytokine receptor family
  • five potential N-linked glycosylation sites
  • HOMOLOGY
    intraspecies homolog to IL22R1
    IL1OR
    Homologene
    FAMILY claa II cytokine receptor family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing an important role as an IL22 antagonist in the regulation of inflammatory response
  • plays a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon
  • IL22 and IL22RA2 are regulated during intestinal tissue damage
  • promotes bacterial uptake into Peyer patches (PPs) by influencing follicle-associated epithelium (FAE) gene expression and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL22 (blocking its interaction with cell surface IL22R complex)
  • regulation of IL22RA2 is crucial to control the effects of IL22 during intestinal tissue damage and tumorigenesis
  • IL22RA2 is a soluble IL22 receptor, which antagonizes IL22 activity and has genetic associations with autoimmune diseases
  • cell & other
    REGULATION
    Other regulation of IL22RA2 via the inflammasome provides an unanticipated mechanism, controlling IL22 and thereby the development of colon cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    IL22RA2 is a new relevant therapeutic target in nflammatory bowel diseases (IBDs)
    ANIMAL & CELL MODELS