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FLASH GENE
Symbol MYCNOS contributors: npt - updated : 29-04-2003
HGNC name v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand
HGNC id 16911
Location 2p24.1      Physical location : 16.080.019 - 16.081.845
Synonym name
  • DNA-binding transcriptional activator
  • N-cym protein
    • Synonym symbol(s) NCYM, CYMN
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene, antisens
    STRUCTURE 0.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two polyadenylation sites and multiple 5-prime ends (Armstrong, 1992)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines tumor cell lines containing amplified N-myc loci highly
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, lung, liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • a helix-loop-helix motif
  • a basic region
    • HOMOLOGY
    interspecies homolog to C.elegans W05E10.2
    Homologene
    FAMILY
    CATEGORY DNA associated , protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having a functional role during normal fetal development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text normal development and oncogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other expression coregulated with MYCN gene in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS