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FLASH GENE
Symbol TGM5 contributors: mct/npt - updated : 05-06-2019
HGNC name transglutaminase 5
HGNC id 11781
Corresponding disease
APSS acral peeling skin syndrome
Location 15q15.2      Physical location : 43.524.792 - 43.559.055
Synonym name
  • TGase 5
  • TGase X
  • Transglutaminase X
  • Synonym symbol(s) TGX, TGM6, TGMX, MGC141907
    EC.number 2.3.2.13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with EPB42 and TGM7
    STRUCTURE 33.68 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1939 - 638 - -
    13 - 2185 - 720 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Reproductivefemale system    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumenthair follicle cell
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tgm5
    Homologene
    FAMILY
  • transglutaminase superfamily
  • transglutaminase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the cross-linking of proteins and the conjugation of polyamines to proteins
  • contributing to the formation of the cornified cell envelope of keratinocytes
  • having function vital for maintaining cell-cell adhesion between the outermost layers of the epidermis
  • involved in signal transduction and, like two other TGs (TGM3 and TGM5), is able to bind and hydrolyze guanosine triphosphate (Zocchi 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APSS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS