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FLASH GENE

Symbol

CADM4

contributors: mct/ - updated : 24-03-2013

HGNC name	cell adhesion molecule 4
HGNC id	30825

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.31      Physical location : 44.126.521 - 44.143.991
Synonym name	TSLC1-like 2
	immunoglobulin superfamily, member 4C
	nectin-like 4
Synonym symbol(s)	TSLL2, synCAM4, IGSF4C, Necl-4, NECL4

DNA

TYPE	functioning gene
STRUCTURE	17.47 kb     9 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145296 9 - 2176 NP_660339 - 388 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine     highly Homo sapiens   intestine small intestine     highly Homo sapiens Nervous brain       highly Reproductive female system breast mammary gland   highly Urinary kidney tubule convoluted tubule proximal tubule highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous Schawnn cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two ig-like c2-type (immunoglobulin-like) domains
	one ig-like v-type (immunoglobulin-like) domain
	a single transmembrane domain
	a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif

HOMOLOGY

interspecies

ortholog to murine Igsf4c

intraspecies

homolog to NECL1

Homologene

FAMILY	TSLC1 gene family
	nectin-like family
	CADM-family protein

CATEGORY

adhesion , tumor suppressor , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier
	acting as a homophilic cell-adhesion molecule
	playing a role in early neuronal differentiation and axon outgrowth
	functioning as adhesion molecule
	playing an important role for mediating axon-glia contact during myelination in peripheral nerves
	mediates the Schwann cell-axon interactions necessary for myelination
	could play an important role in cell-cell interaction as well as in tumor suppression
	key role for CADM4 in initiating peripheral nervous system myelination and the Necl proteins are mediators of axo-glial interactions along the internode
	with CADM3, suppress the growth and tumorigenic ability of colon cancer cells
	cascade of CADM4 and EPB41L3 plays an important role in normal cell adhesion of the proximal tubules
	is a novel tumor suppressor candidate in renal clear cell carcinoma acting with its binding partner EPB41L3

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	glial binding partner for axonal CADM3
	interacting with EPB41L2 (plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with CADM4 on Sertoli cells)
	MAG together with other adhesion molecules such as CADM4 is important in sustaining axonal integrity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function in glioma and prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS