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FLASH GENE
Symbol LRRC1 contributors: mct - updated : 14-12-2016
HGNC name leucine-rich repeat-containing 1
HGNC id 14307
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • sixteen leucine rich repeats
  • no PDZ domain
    • HOMOLOGY
    Homologene
    FAMILY LAP protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text basolateral side
    basic FUNCTION
  • participating to homeostasis of epithelial tissues and tumor growth
  • ERBIN, LRRC1, and SCRIB act at the post-synaptic membrane of NMJs in a concerted fashion to regulate nicotinic acetylcholine receptors cluster morphology and neural transmission
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • LANO/CASK complex
  • ERBBPIP/lLANO complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein CASK by PDZ domain
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased the tumorigenicity of hepatocellular carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    contributes to hepatocellular carcinoma development, and may be a potential target for therapeutic intervention in this disease
    ANIMAL & CELL MODELS