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FLASH GENE

Symbol

LRRC1

contributors: mct - updated : 14-12-2016

HGNC name	leucine-rich repeat-containing 1
HGNC id	14307

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	129.63 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018214 14 - 3180 NP_060684 59.2 524 - 2001 11440998 variant 2 - - 2527 - 197 - 2001 11440998

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	sixteen leucine rich repeats
	no PDZ domain

HOMOLOGY

Homologene

FAMILY

LAP protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	basolateral side

basic FUNCTION	participating to homeostasis of epithelial tissues and tumor growth
	ERBIN, LRRC1, and SCRIB act at the post-synaptic membrane of NMJs in a concerted fashion to regulate nicotinic acetylcholine receptors cluster morphology and neural transmission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	LANO/CASK complex
	ERBBPIP/lLANO complex

INTERACTION

DNA

RNA

small molecule

protein

CASK by PDZ domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   increased the tumorigenicity of hepatocellular carcinoma cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver contributes to hepatocellular carcinoma development, and may be a potential target for therapeutic intervention in this disease

ANIMAL & CELL MODELS