SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| text
| brain-specific isoform located in the endoplasmic reticulum of neurons  |
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located in the endoplasmic reticulum throughout the neuron, even inside dendritic spines |
| basic FUNCTION
| playing a role in neural tissue fatty acid metabolism and in feeding behavior or appetite control |
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participates in a biosynthetic pathway, facilitating the constant transport of palmitate across the ER membrane, rather than in a highly active catabolic pathway such as fatty acid oxidation |
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necessary for the regulation of energy homeostasis |
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can elicit profound effects on brain physiology and total fatty acid profiles |
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is implicated in malonyl-CoA action in leptin hypothalamic anorectic signaling pathways |
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implicated in the hypothalamic regulation of food intake and energy homeostasis |
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regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons, and this is a relevant mechanism for the correct maturation of dendritic spines and for proper spatial learning |
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couples malonyl-CoA to ceramide levels thereby contributing to systemic energy homeostasis and feeding behavior |
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plays a role as a novel regulator of AMPAR surface expression in neurons |
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is a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus |
