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FLASH GENE

Symbol

UCK1

contributors: mct - updated : 04-07-2023

HGNC name	uridine-cytidine kinase
HGNC id	14859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 2700 - - ubiquitous Van Rompay - - - 1800 - - skeletal muscle,heart,liver,kidney Van Rompay - - - 1200 - - only placenta Van Rompay - - - 2000 - - only placenta Van Rompay NM_001261450 7 - 2135 NP_001248379 - 268 - 2016 27239701 NM_001261451 7 - 2177 NP_001248380 - 282 - 2016 27239701 NM_001318519 7 - 2093 NP_001305448 - 254 - 2016 27239701 NM_001135954 6 - 2067 NP_001129426 - 201 - 2016 27239701 NM_031432 7 - 2162 NP_113620 - 277 - 2016 27239701

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to yeast uck

Homologene

FAMILY

uridine kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in the phosphorylation of nucleoside analogs
	UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS