Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UCK1 contributors: mct - updated : 04-07-2023
HGNC name uridine-cytidine kinase
HGNC id 14859
Location 9q34.13      Physical location : 134.399.183 - 134.406.662
Synonym name
  • cytidine monophosphokinase 1
  • uridine monophosphokinase 1
    • Synonym symbol(s) URK1, FLJ12255, RP11-334J6.5
    EC.number 2.7.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 7.46 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2700 - - ubiquitous Van Rompay
    - - - 1800 - - skeletal muscle,heart,liver,kidney Van Rompay
    - - - 1200 - - only placenta Van Rompay
    - - - 2000 - - only placenta Van Rompay
    7 - 2135 - 268 - 2016 27239701
    7 - 2177 - 282 - 2016 27239701
    7 - 2093 - 254 - 2016 27239701
    6 - 2067 - 201 - 2016 27239701
    7 - 2162 - 277 - 2016 27239701
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast uck
    Homologene
    FAMILY uridine kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the phosphorylation of nucleoside analogs
  • UCK1, UCK2, play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS