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FLASH GENE
Symbol SCARF2 contributors: mct - updated : 26-10-2010
HGNC name scavenger receptor class F, member 2
HGNC id 19869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple epidermal growth factor-like domain
  • seven EGF-like domains
  • putative epidermal growth factor-like domains in its extracellular domain, along with a number of positively charged residues in its intracellular domain
    • HOMOLOGY
    intraspecies homolog to SCARF1 (highly)
    Homologene
    FAMILY scavenger receptor type F family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • internalizing modified low density lipoproteins (LDL)
  • may be involved in intracellular signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to acetylated LDL and oxidized LDL
  • heterophilic interaction between SCARF1 and SCARF2 at their extracellular domains
  • SCARF1 and SCARF2, show weak cell-cell interaction by their extracellular domains (termed homophilic trans-interaction) but display strong heterophilic trans-interaction through the extracellular epidermal growth factor-like repeat domains
    • cell & other
    REGULATION
    activated by in the presence of oxidized LDL
    ASSOCIATED DISORDERS
    corresponding disease(s) VDEGS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS