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FLASH GENE
Symbol ZFP64 contributors: mct - updated : 10-11-2010
HGNC name zinc finger protein 64 homolog (mouse)
HGNC id 15940
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten zinc finger motifs of the C2H2 Kruppel type
  • multiple phosphorylation sites
    • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp36
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of NOTCH1, and potentialy mediates mesenchymal cell differentiation by modulating NOTCH1 signaling
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ZN2+ binding
    protein
  • associated with the intracellular domain of NOTCH1, recruited to the promoters of the NOTCH1 target genes HES1 and HEY1, and transactivates them
  • downstream target of RUNX2
    • cell & other
    REGULATION
    Other regulated by RUNX2 (expression under the control of RUNX2, and is upregulated by direct transactivation of its promoter)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS