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FLASH GENE

Symbol

ZFP64

contributors: mct - updated : 10-11-2010

HGNC name	zinc finger protein 64 homolog (mouse)
HGNC id	15940

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	107.98 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018197 6 splicing 3281 NP_060667 74.6 681 - 1997 9034307 also called isoform a NM_022088 5 - 3119 NP_071371 68.6 627 - 1997 9034307 also called isoform b NM_199426 6 - 3275 NP_955458 74.5 679 - 1997 9034307 also called isoform c NM_199427 9 - 2967 NP_955459 72.2 645 - 1997 9034307 also called isoform d

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten zinc finger motifs of the C2H2 Kruppel type
	multiple phosphorylation sites

conjugated

MetalloP

HOMOLOGY

interspecies

ortholog to murine Zfp36

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

coactivator of NOTCH1, and potentialy mediates mesenchymal cell differentiation by modulating NOTCH1 signaling

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	ZN2+ binding

protein	associated with the intracellular domain of NOTCH1, recruited to the promoters of the NOTCH1 target genes HES1 and HEY1, and transactivates them
	downstream target of RUNX2

cell & other

REGULATION

Other

regulated by RUNX2 (expression under the control of RUNX2, and is upregulated by direct transactivation of its promoter)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS