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FLASH GENE
Symbol IGHG3 contributors: - updated : 17-06-2006
HGNC name immunoglobulin heavy constant gamma 3 (G3m marker)
HGNC id 5527
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION
basic FUNCTION antigen binding
immune response
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • forming an homodimer of two D heavy chains bound by an unique disulfide bond
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS