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FLASH GENE

Symbol

ZDHHC3

contributors: mct/npt/pgu - updated : 09-01-2018

HGNC name	zinc finger, DHHC-type containing 3
HGNC id	18470

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	50.95 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016598 8 - 12714 NP_057682 - 327 - 2002 12163046 NM_001135180 7 - 3926 NP_001128652 - 329 - 2002 12163046 NM_001135179 7 - 12630 NP_001128651 - 299 - 2002 12163046

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved Cys 4 zinc-finger like metal binding domain
	a complex Cys-His region
	DHHC/NEW1 domain
	potentially involved in protein-protein or protein-DNA interaction
	four transmembrane segments

HOMOLOGY

interspecies

homolog to Drosophila DNZ1

Homologene

FAMILY	DHHC/GODZ subfamily
	DHHC palmitoyltransferase family

CATEGORY

enzyme , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
text	with ZDHHC17, co-localized to the Golgi and the same post-Golgi vesicles, suggesting that heteropalmitoylation might play a physiological role in addition to a biochemical function

basic FUNCTION	putative transcription factor playing a role in the membrane protein trafficking
	DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse substrates that function either at inhibitory or excitatory synapses
	mediating palmitoylation of GABA(A) receptors and possibly other substrates contributes selectively to the formation and normal function of GABAergic inhibitory synapses
	with ZDHHC2, are differentially regulated and dynamic recruitment of protein palmitoylation machinery enables compartmentalized regulation of protein trafficking in response to extracellular signals
	mediates the palmitoylation and post-translational modification of many protein substrates that regulate membrane-protein interactions
	encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates
	co-expression of DHHC acyltransferases (DHHC3 or DHHC7), but not their acyltransferase-inactive mutants, increased expression levels of RGS4
	may potentially undergo some post-translational modification following its exit from the ER
	DHHC3 localized to ER membranes is an active palmitoyltransferase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	involved in the palmitoylation of SNAP25
	palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6/beta4
	ZDHHC3 and ZDHHC8, also interacted with the DRD2 and each of the palmitoyl acyltransferase (PAT) was capable of affecting the palmitoylation status of the DRD2
	ZDHHC3 promotes breast tumor growth, by a mechanism involving palmitoylation of key substrate proteins such as ERGIC3
	Cys141 and Cys498 AAs on ACE2 are S-palmitoylated by ZDHHC3 and de-palmitoylated by LYPLA1, which is critical for the membrane-targeting of ACE2 and their extracellular vesicles (EVs) secretion to interacts with the viral spike (S) protein of the SARS-CoV-2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS