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FLASH GENE
Symbol ZDHHC11 contributors: mct/npt - updated : 13-02-2016
HGNC name zinc finger, DHHC domain containing 11
HGNC id 19158
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region, DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction
    • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative transcription factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+ binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    tumoral   amplification    
    in high-grade bladder cancers (Yamamoto 2007)
    constitutional     --over  
    promoted the palmitoylation of SARS-CoV-2 S, establishing role of S palmitoylation in syncytia formation and virus entry
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential biomarker identifying high-risk patients with disease progression in bladder cancer (Yamamoto 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS