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FLASH GENE

Symbol

IGHG1

contributors: mct - updated : 24-10-2017

HGNC name	immunoglobulin heavy constant gamma 1 (G1m marker)
HGNC id	5525

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Visual eye anterior segment cornea

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune immunocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	forming an homodimer of two D heavy chains bound by an unique disulfide bond
	each heavy chain is bound to a light chain (kappa or lambda)
	the N terminus of the heavy chain is bound to a V segment

INTERACTION

DNA

RNA

small molecule

protein

PHB/PHB2 and the CD86 cytoplasmic domain cooperate to mediate CD86 signaling in a B cell through differential phosphorylation of distal signaling intermediates required to increase IGHG1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     IGHG1/CCND1 in t(11;14)in B-cell chronic lymphocytic leukemia;IGHG1/LHX4 in t(1;14); IGHG1/FOXP1 in t(3;14)in a sub-class of MALT lymphomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS