basic FUNCTION
| may have direct activity on the actin cytoskeleton and inducing actin polymerization and redistribution |
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playing an important role in the intracellular motility |
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of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus |
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stabilizes WAS and may also be important for its function |
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essential for IL2 signaling and responsiveness in T cells, possibly because of its critical role in TCR-triggered actin cytoskeletal reorganization (le Bras 2009) |
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plays, independently of WAS, a critical role in T cell activation by antigen, IL2 signaling and responsiveness, and cytoskeletal rearrangement (Le Bras 2009) |
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actin-binding protein involved in the regulation of actin polymerization in cells, such as fibroblasts and lymphocytes |
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is a previously unreported regulator of neuronal maturation and synaptic activity |
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WAS and WIPF1 localise to the actin rich core of podosomes and play a critical role in their formation |
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involvement in the control of migratory persistence in both mesenchymal (fibroblast) and amoeboid (B lymphocytes) motility |
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is a novel regulator of focal adhesion (FA) assembly and cell adhesion |
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key role in actin polymerization in activated T cells |