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FLASH GENE

Symbol

UCKL1

contributors: mct - updated : 20-02-2012

HGNC name	uridine-cytidine kinase 1-like 1
HGNC id	15938

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.33      Physical location : 62.571.190 - 62.587.800
Synonym name	uridine kinase-like 1
Synonym symbol(s)	FLJ20517, URKL1, UCK1L
EC.number	2.7.1.48

DNA

TYPE	functioning gene
STRUCTURE	16.62 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017859 15 - 1885 NP_060329 61 548 - 2009 19653100 NM_001193379 15 - 2113 NP_001180308 - 533 - 2009 19653100

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

uridine kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	RNF19B and UCKL1 interact in the tumor cell, where degradation of UCKL1 leads to increased tumor cell apoptosis
	role in tumor cell survival, suggesting possible therapeutic potential of UCKL1 inhibitors in cancer treatment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	substrate of RNF19B
	interacting with RNF19B (binds to and ubiquitinates a novel protein, uridine-cytidine kinase like-1 (UCKL1), targeting it for degradation)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS