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FLASH GENE
Symbol UCKL1 contributors: mct - updated : 20-02-2012
HGNC name uridine-cytidine kinase 1-like 1
HGNC id 15938
Location 20q13.33      Physical location : 62.571.190 - 62.587.800
Synonym name uridine kinase-like 1
Synonym symbol(s) FLJ20517, URKL1, UCK1L
EC.number 2.7.1.48
DNA
TYPE functioning gene
STRUCTURE 16.62 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 1885 61 548 - 2009 19653100
15 - 2113 - 533 - 2009 19653100
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • uridine kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • RNF19B and UCKL1 interact in the tumor cell, where degradation of UCKL1 leads to increased tumor cell apoptosis
  • role in tumor cell survival, suggesting possible therapeutic potential of UCKL1 inhibitors in cancer treatment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of RNF19B
  • interacting with RNF19B (binds to and ubiquitinates a novel protein, uridine-cytidine kinase like-1 (UCKL1), targeting it for degradation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS