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FLASH GENE
Symbol UNC5D contributors: mct/npt - updated : 04-10-2022
HGNC name unc-5 homolog D (C. elegans)
HGNC id 18634
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Endocrinepancreas    
Nervousbrain    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a death domain motif
  • a canonical caspase cleavage site (413-DVID-416) in its cytoplasmic region, playing an important role in the induction of apoptosis
    • HOMOLOGY
    Homologene
    FAMILY
  • dependence receptor family
  • unc-5 family
    • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • having serine protease inhibitor activity, and involved in signal transduction
  • may be having a role in laminar specification of cortical cells and circuitry
  • is a newly identified transcriptional target of pro&
    • 8209;apoptotic TP53 and may also act upstream of TP53 to induce TP53&
    8209;dependent apoptosis by phosphorylation at ser&
    8209;15
  • involvement of UNC5D gene in the severe myopic anisometropia
  • UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLRT2 interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
  • PRDM8 expression was almost coincident with UNC5D expression, a marker for the late multipolar phase
  • direct transcriptional target of TP53 (amplifies TP53-dependent apoptotic response)
  • UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
  • UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in end-stage dilated cardiomyopathy (Colak 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KCNA1 and UNC5D promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer
    • Therapy target
    ANIMAL & CELL MODELS