Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

UNC5D

contributors: mct/npt - updated : 04-10-2022

HGNC name	unc-5 homolog D (C. elegans)
HGNC id	18634

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_080872 17 - 9149 NP_543148 - 953 - 2017 28754176 NM_001322818 17 - 8880 NP_001309747 - 948 - 2017 28754176 NM_001410918 15 - 8948 NP_001397847 - 886 - 2017 28754176

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Endocrine pancreas         Nervous brain         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a death domain motif
	a canonical caspase cleavage site (413-DVID-416) in its cytoplasmic region, playing an important role in the induction of apoptosis

HOMOLOGY

Homologene

FAMILY	dependence receptor family
	unc-5 family

CATEGORY

regulatory , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	having serine protease inhibitor activity, and involved in signal transduction
	may be having a role in laminar specification of cortical cells and circuitry
	is a newly identified transcriptional target of pro&
	8209;apoptotic TP53 and may also act upstream of TP53 to induce TP53&
	8209;dependent apoptosis by phosphorylation at ser&
	8209;15
	involvement of UNC5D gene in the severe myopic anisometropia
	UNC5A, UNC5B, UNC5C and UNC5D encode dependence receptors that regulate the apoptosis/survival balance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	FLRT2 interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
	PRDM8 expression was almost coincident with UNC5D expression, a marker for the late multipolar phase
	direct transcriptional target of TP53 (amplifies TP53-dependent apoptotic response)
	UNC5A, UNC5B, UNC5C, UNC5D and ADGRL3 can simultaneously bind to FLRT3, forming a trimeric complex, and FLRT3 may form transsynaptic complexes with both ADGRL3 and UNC5
	UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in end-stage dilated cardiomyopathy (Colak 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	KCNA1 and UNC5D promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer
Therapy target

ANIMAL & CELL MODELS