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FLASH GENE
Symbol UBR1 contributors: mct/npt - updated : 16-02-2009
HGNC name ubiquitin protein ligase E3 component n-recognin 1
HGNC id 16808
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • N-recognin called E3-alpha domain
  • one UBR1-type zinc finger, 70-AAs UBR box functioning as a common structural element essential for binding to all known destabilizing N-terminal residues (Tasaki 2009)
  • a RING-H2 domain
  • a BRR (basic residues rich) region
  • HOMOLOGY
    interspecies ortholog to murine Ubr1
    homolog to chimpanzee LOC453369
    Homologene
    FAMILY
  • UBR1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ubiquitin ligase binding to proteins bearing amino-terminal residues that are destabilizing according to the n-end rule, but does not bind to otherwise identical proteins bearing stabilizing amino-terminal residues
  • having a critical role for the regulation of FOS (Sasaki 2006)
  • also participates in H2A ubiquitination during meiosis (An2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • complexing with RECQL4 in both nucleus and cytoplasm
  • cell & other
    REGULATION
    induced by STAT3 (Sasaki 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s) JBS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS