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FLASH GENE
Symbol UBR1 contributors: mct/npt - updated : 16-02-2009
HGNC name ubiquitin protein ligase E3 component n-recognin 1
HGNC id 16808
DNA
TYPE functioning gene
STRUCTURE 163.19 kb     47 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D15S760 - D15S748 - UBR1 - D15S759 - D15S508 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
47 - 7758 200 1749 - Beausoleil (2004)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate  highly
 male systemtestis  predominantly
Respiratoryrespiratory tractlarynx  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • N-recognin called E3-alpha domain
  • one UBR1-type zinc finger, 70-AAs UBR box functioning as a common structural element essential for binding to all known destabilizing N-terminal residues (Tasaki 2009)
  • a RING-H2 domain
  • a BRR (basic residues rich) region
  • HOMOLOGY
    interspecies ortholog to murine Ubr1
    homolog to chimpanzee LOC453369
    Homologene
    FAMILY
  • UBR1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ubiquitin ligase binding to proteins bearing amino-terminal residues that are destabilizing according to the n-end rule, but does not bind to otherwise identical proteins bearing stabilizing amino-terminal residues
  • having a critical role for the regulation of FOS (Sasaki 2006)
  • also participates in H2A ubiquitination during meiosis (An2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • complexing with RECQL4 in both nucleus and cytoplasm
  • cell & other
    REGULATION
    induced by STAT3 (Sasaki 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s) JBS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS