Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBE2E1 contributors: mct - updated : 26-10-2011
HGNC name ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
HGNC id 12477
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY E2 ubiquitin-conjugating enzyme family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
text
  • UBE2E1 is localized to the nucleus
    • basic FUNCTION
  • E2 enzymes for ubiquitin conjugation, that may be involved in the ubiquitination of various proteins
  • modulates the transcriptional repression activity of ATXN1 by modulating the degradation of ATXN1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UBE2E1-RNF167 may define a novel ubiquitin-proteasome pathway that targets SLC22A18 in cells
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UBE3A
  • interacts with and ubiquitinates ATXN1, the spinocerebellar ataxia type 1 gene product (could ubiquitinate ataxin-1 in the absence of an E3 ligase and modulates its stability)
  • UBE2E1, RNF20/40, and the PAF1 complex are recruited to transcriptionally active genes
  • TRIM21 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS