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FLASH GENE
Symbol UBE2E1 contributors: mct - updated : 26-10-2011
HGNC name ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
HGNC id 12477
Location 3p24.2      Physical location : 23.847.438 - 23.932.802
Synonym name
  • ubiquitin carrier protein E1
  • ubiquitin-protein ligase E1
    • Synonym symbol(s) UBCH6
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 85.75 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1845 - 193 - 2005 16428300
    5 - 1794 - 176 - 2005 16428300
    - - 1550 - 160 - 2005 16428300
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY E2 ubiquitin-conjugating enzyme family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • UBE2E1 is localized to the nucleus
    • basic FUNCTION
  • E2 enzymes for ubiquitin conjugation, that may be involved in the ubiquitination of various proteins
  • modulates the transcriptional repression activity of ATXN1 by modulating the degradation of ATXN1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UBE2E1-RNF167 may define a novel ubiquitin-proteasome pathway that targets SLC22A18 in cells
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with UBE3A
  • interacts with and ubiquitinates ATXN1, the spinocerebellar ataxia type 1 gene product (could ubiquitinate ataxin-1 in the absence of an E3 ligase and modulates its stability)
  • UBE2E1, RNF20/40, and the PAF1 complex are recruited to transcriptionally active genes
  • TRIM21 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS