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FLASH GENE
Symbol UBE2D3 contributors: mct/npt/pgu - updated : 01-02-2015
HGNC name ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
HGNC id 12476
Location 4q24      Physical location : 103.717.133 - 103.790.032
Synonym name
  • ubiquitin carrier protein
  • ubiquitin-protein ligase D3
  • ubiquitin-conjugating enzyme E2-17 kDa 3
    • Synonym symbol(s) UBCH5C, E2(17)KB3, MGC43926, MGC5416, UBC4/5
    EC.number 6.3.2.19
    DNA
    TYPE functioning gene
    STRUCTURE 72.90 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map qter - D4S3043 - D4S1572 - UBE2D3 - D4S2913 - D4S2907 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2383 - 147 - 2004 15280377
    8 - 2591 - 147 - 2004 15280377
    8 - 2359 - 147 - 2004 15280377
    8 - 2240 - 147 - 2004 15280377
    8 - 2233 - 147 - 2004 15280377
    8 - 2187 - 147 - 2004 15280377
    8 - 2151 - 147 - 2004 15280377
    8 - 2623 - 148 - 2004 15280377
    7 - 2006 - 149 - 2004 15280377
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • physiological ubiquitin-conjugating enzymes E2s for MDM2, which make a significant contribution to the maintenance of low levels of TP53 and MDM2 in unstressed cells
  • regulates DAPK3 accumulation in promyelocytic leukemia protein nuclear body (PML-NB) by interacting with DAPK3 and stimulating its ubiquitination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DAPK3-binding partner (induced ubiquitination of DAPK3)
  • interacts with RNF2, in a manner fairly typical of E2-E3 interactions
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
    • cell & other
    REGULATION
    repressed by SNAI2 (directly represses the promoter of the UBE2D3 gene)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS