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FLASH GENE
Symbol UBE2D2 contributors: mct/npt - updated : 02-10-2018
HGNC name ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
HGNC id 12475
Location 5q31.2      Physical location : 138.940.750 - 139.008.016
Synonym name
  • ubiquitin-conjugating enzyme E2-17 kDa 2
  • ubiquitin-conjugating enzyme E2D 2
  • ubiquitin-conjugating enzyme E2-17 kDa 2
    • Synonym symbol(s) UBC4, UBCH5B, PUBC1, UBC4/5, E2(17)KB2
    EC.number 6.3.2.19
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 67.27 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2715 - 147 - Chiang (2008)
    8 - 2879 - 118 - Chiang (2008)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • functional E2 protein which, together with FBXW2, regulates GCM1 stability in the placenta (Chiang 2008)
  • physiological ubiquitin-conjugating enzymes E2s for MDM2, which make a significant contribution to the maintenance of low levels of TP53 and MDM2 in unstressed cells (Saville 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS