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FLASH GENE

Symbol

TUBGCP3

contributors: mct - updated : 16-12-2016

HGNC name	tubulin, gamma complex associated protein 3
HGNC id	18598

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	103.18 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001286277 22 - 3898 NP_001273206 - 897 - - NM_006322 22 - 3928 NP_006313 - 907 - - NM_001286278 21 - 2796 NP_001273207 - 824 - - NM_001286279 10 - 2529 NP_001273208 - 439 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial barrier/lining retinal pigment epithelium (RPE)     Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage	germinal center B cell lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an hydrophobic motif is present in the N-terminus

HOMOLOGY

Homologene

FAMILY

GCP family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle

basic FUNCTION

necessary for microtublule nucleation at the centrosome

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

TUBGCP2, TUBGCP3 formed complexes with gamma-tubulin in the nucleoli

INTERACTION

DNA

RNA

small molecule

protein	UTP6 N-terminal region indirectly associated with gamma-tubulin through binding with gamma-tubulin complex protein 2 (TUBGCP2) and/or TUBGCP3
	MST1 contributes to the microtubule-organizing centers (MTOCs) function through regulation of TUBGCP3
	recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   caused accumulation of cells in G2/M and mitotic delay but did not affect nucleolar integrity tumoral     --over   in the expression of TUBGCP2 and TUBGCP3 transcripts in glioblastoma cells versus normal human astrocytes

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS