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FLASH GENE

Symbol

TUBGCP3

contributors: mct - updated : 16-12-2016

HGNC name	tubulin, gamma complex associated protein 3
HGNC id	18598

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q34      Physical location : 113.139.327 - 113.242.481
Synonym name	spindle pole body protein Spc98 homolog
Synonym symbol(s)	GCP3, SPC98P, SPBC98, Alp4

DNA

TYPE	functioning gene
STRUCTURE	103.18 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001286277 22 - 3898 NP_001273206 - 897 - - NM_006322 22 - 3928 NP_006313 - 907 - - NM_001286278 21 - 2796 NP_001273207 - 824 - - NM_001286279 10 - 2529 NP_001273208 - 439 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial barrier/lining retinal pigment epithelium (RPE)     Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage	germinal center B cell lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an hydrophobic motif is present in the N-terminus

HOMOLOGY

Homologene

FAMILY

GCP family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle

basic FUNCTION

necessary for microtublule nucleation at the centrosome

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

TUBGCP2, TUBGCP3 formed complexes with gamma-tubulin in the nucleoli

INTERACTION

DNA

RNA

small molecule

protein	UTP6 N-terminal region indirectly associated with gamma-tubulin through binding with gamma-tubulin complex protein 2 (TUBGCP2) and/or TUBGCP3
	MST1 contributes to the microtubule-organizing centers (MTOCs) function through regulation of TUBGCP3
	recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   caused accumulation of cells in G2/M and mitotic delay but did not affect nucleolar integrity tumoral     --over   in the expression of TUBGCP2 and TUBGCP3 transcripts in glioblastoma cells versus normal human astrocytes

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS