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FLASH GENE
Symbol IGHE contributors: - updated : 17-06-2006
HGNC name immunoglobulin heavy constant epsilon
HGNC id 5522
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticbasophil
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains four Ig domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Igh7
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION     plasma membrane
text plasma membrane of mast cells
basic FUNCTION immunity against parasites
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS immunity/defense
PATHWAY
metabolism
signaling
a component
  • forming an homodimer of two E heavy chains bound by two disulfide bonds
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS