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FLASH GENE

Symbol

IGHE

contributors: - updated : 17-06-2006

HGNC name	immunoglobulin heavy constant epsilon
HGNC id	5522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.33      Physical location : -
Synonym symbol(s)	HGNC5522, IGE

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	member of the IGH constant gene cluster

MAPPING

cloned

Y

linked

status

confirmed

Map

see IGHC@

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic basophil

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four Ig domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Igh7

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
text	plasma membrane of mast cells

basic FUNCTION

immunity against parasites

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component	forming an homodimer of two E heavy chains bound by two disulfide bonds
	each heavy chain is bound to a light chain (kappa or lambda)
	the N terminus of the heavy chain is bound to a V segment

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS