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FLASH GENE
Symbol IGHE contributors: - updated : 17-06-2006
HGNC name immunoglobulin heavy constant epsilon
HGNC id 5522
Location 14q32.33      Physical location : -
Synonym symbol(s) HGNC5522, IGE
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of the IGH constant gene cluster
MAPPING cloned Y linked   status confirmed
Map see IGHC@
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticbasophil
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains four Ig domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Igh7
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION     plasma membrane
text plasma membrane of mast cells
basic FUNCTION immunity against parasites
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS immunity/defense
PATHWAY
metabolism
signaling
a component
  • forming an homodimer of two E heavy chains bound by two disulfide bonds
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS