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FLASH GENE
Symbol TRIP4 contributors: mct - updated : 16-03-2016
HGNC name thyroid hormone receptor interactor 4
HGNC id 12310
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved cysteine-rich Zn-chelating domain, which binds transcription factors
  • a conserved C-terminal domain, which harbors a RNA-binding PUA domain thought to be an ancient structural motif for RNA-protein interactions
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    text
  • nuclear protein that localized into the cytoplasm under conditions of serum deprivation
    • basic FUNCTION
  • initially identified as a transcriptional coactivator of the thyroid hormone receptor
  • TRIP4 and ASCC1 are indispensable for motor system development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of TRIP4 complex containing ASCC1, ASCC2 and ASCC3, the activating signal cointegrator 1 (ASC-1) complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between TRIP4 and SRF, which seemed to offer a functional link between genetic defect and disease phenotype because SRF is an essential transcription factor for muscle, nervous system, and bone development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCSMA2
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP
  • rs74615166) is a novel genome-wide significant locus for Alzheimer disease risk
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS