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FLASH GENE

Symbol

TRIP4

contributors: mct - updated : 16-03-2016

HGNC name	thyroid hormone receptor interactor 4
HGNC id	12310

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	67.50 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016213 13 - 2057 NP_057297 - 581 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Mus musculus Nervous brain forebrain cerebral cortex     Mus musculus   ganglia sensory ganglia dorsal root     Mus musculus   ganglia autonomic ganglia sympathetic     Mus musculus   spinal cord         Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved cysteine-rich Zn-chelating domain, which binds transcription factors
	a conserved C-terminal domain, which harbors a RNA-binding PUA domain thought to be an ancient structural motif for RNA-protein interactions

HOMOLOGY

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleoplasm
text	nuclear protein that localized into the cytoplasm under conditions of serum deprivation

basic FUNCTION	initially identified as a transcriptional coactivator of the thyroid hormone receptor
	TRIP4 and ASCC1 are indispensable for motor system development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of TRIP4 complex containing ASCC1, ASCC2 and ASCC3, the activating signal cointegrator 1 (ASC-1) complex

INTERACTION

DNA

RNA

small molecule

protein

interaction between TRIP4 and SRF, which seemed to offer a functional link between genetic defect and disease phenotype because SRF is an essential transcription factor for muscle, nervous system, and bone development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AMCSMA2

Susceptibility

to Alzheimer disease

Variant & Polymorphism SNP	rs74615166) is a novel genome-wide significant locus for Alzheimer disease risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS