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FLASH GENE
Symbol TP53INP1 contributors: mct - updated : 14-05-2014
HGNC name tumor protein p53 inducible nuclear protein 1
HGNC id 18022
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Trp53inp1 (86.2 pc)
homolog to murine Trp53inp1 (87.9 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,PML
text
  • mainly nuclear, but relocalizes in autophagosomes during autophagy where it is eventually degraded
    • basic FUNCTION
  • promoting p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis, in response to double-strand DNA breaks
  • associated with TP73 to regulate cell cycle progression and apoptosis, independently from TP53
  • regulating TP53 transcriptional activity
  • stress-induced protein that plays a role in both cell cycle arrest and TP53-mediated apoptosis
  • having a novel activity on the regulation of SPARC expression that could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
  • could act as a tumor suppressor by inducing cell death by caspase-dependent autophagy
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIPK2
  • interacting with the p53
  • MYC bound to the core promoter of TP53INP1 and recruited DNA methyltransferase 3A to methylate the local promoter region, leading to the inhibition of TP53INP1 expression
  • interacts physically with TP53 and is a major player in the TP53-driven oxidative stress response
  • able to interact with ATG8-family proteins and to induce autophagy-dependent cell death
    • cell & other
    REGULATION
    induced by adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way
    ultraviolet irradiation, at lower levels
    Other upregulated by ZBTB16
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in pancreatic cancer (
    tumoral     --over  
    is a worse prognostic factor in prostate carcinoma, particularly predictive of biological cancer relapse
    tumoral     --low  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be considered as potential markers of breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    could be considered as a relevant-specific target for molecular therapy of castration-resistant prostate cancer
    ANIMAL & CELL MODELS