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FLASH GENE

Symbol

TP53INP1

contributors: mct - updated : 14-05-2014

HGNC name	tumor protein p53 inducible nuclear protein 1
HGNC id	18022

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q22.1      Physical location : 95.938.200 - 95.961.615
Synonym symbol(s)	SIP, FLJ22139, P53DINP1, Teap, TP53DINP1, TP53INP1A, TP53INP1B

DNA

TYPE	functioning gene
STRUCTURE	23.42 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135733 5 - 5587 NP_001129205 - 164 - 2005 16044147 TP53INP1 beta or SIP18 NM_033285 4 - 5628 NP_150601 27.2 240 - 2005 16044147 TP53INP1 alpha or SIP27

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Digestive liver       highly   mouth tongue     moderately Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly   thymus       predominantly Nervous nerve       highly Reproductive male system testis     moderately Respiratory respiratory tract trachea     moderately Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Trp53inp1 (86.2 pc)
	homolog to murine Trp53inp1 (87.9 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML
text	mainly nuclear, but relocalizes in autophagosomes during autophagy where it is eventually degraded

basic FUNCTION	promoting p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis, in response to double-strand DNA breaks
	associated with TP73 to regulate cell cycle progression and apoptosis, independently from TP53
	regulating TP53 transcriptional activity
	stress-induced protein that plays a role in both cell cycle arrest and TP53-mediated apoptosis
	having a novel activity on the regulation of SPARC expression that could explain in part its tumor suppressor function in pancreatic adenocarcinoma by modulating cellular spreading during the metastatic process
	could act as a tumor suppressor by inducing cell death by caspase-dependent autophagy

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with HIPK2
	interacting with the p53
	MYC bound to the core promoter of TP53INP1 and recruited DNA methyltransferase 3A to methylate the local promoter region, leading to the inhibition of TP53INP1 expression
	interacts physically with TP53 and is a major player in the TP53-driven oxidative stress response
	able to interact with ATG8-family proteins and to induce autophagy-dependent cell death

cell & other

REGULATION

induced by	adriamycin, gamma irradiation and H(2)O(2), in a p53-dependent way
		ultraviolet irradiation, at lower levels

Other

upregulated by ZBTB16

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in pancreatic cancer ( tumoral     --over   is a worse prognostic factor in prostate carcinoma, particularly predictive of biological cancer relapse tumoral     --low   in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be considered as potential markers of breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate could be considered as a relevant-specific target for molecular therapy of castration-resistant prostate cancer

ANIMAL & CELL MODELS