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FLASH GENE
Symbol TIMM22 contributors: mct - updated : 23-05-2019
HGNC name translocase of inner mitochondrial membrane 22 homolog (yeast)
HGNC id 17317
Corresponding disease
TIMM22D TIMM22 deficiency
Location 17p13.3      Physical location : 900.356 - 905.388
Synonym name
  • testis-expressed sequence 4
  • mitochondrial import inner membrane translocase subunit
  • putative membrane protein
  • Synonym symbol(s) TIM22, TEX4
    DNA
    TYPE functioning gene
    STRUCTURE 5.03 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RPH3AL 17p13.3 rabphilin 3A-like (without C2 domains) KPNA2 17q23.1-q23.3 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) LOC390819 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388442 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388449 17 LOC388449 LOC388450 17 similar to Ethanolamine-phosphate cytidylyltransferase (Phosphorylethanolamine transferase) (CTP:phosphoethanolamine cytidylyltransferase) LOC388451 17 hypothetical gene supported by AL137626; NM_016538 LOC388452 17 hypothetical gene supported by BC012327; NM_002359 LOC388314 17 LOC388314 LOC388315 17 hypothetical gene supported by AK128660 MGC45871 17p13 hypothetical protein MGC45871 LOC388316 17 hypothetical gene supported by AK056323 FLJ10979 17p13.3 hypothetical protein FLJ10979 CT120 17p13.3 membrane protein expressed in epithelial-like lung adenocarcinoma GEMIN4 17p13 gem (nuclear organelle) associated protein 4 LOC339253 17p13.3 similar to endozepine-like protein CGI-150 17p13.3 CGI-150 protein FLJ10581 17p13.3 putative RNA methyltransferase NXN 17p13.3 nucleoredoxin TIMM22 17p13 translocase of inner mitochondrial membrane 22 homolog (yeast) ABR 17p13.3 active BCR-related gene MRPL14P1 17p13.3 active BCR-related gene LOC390753 17 similar to putative protein LOC390754 17 similar to hypothetical class II basic helix-loop-helix protein LOST1 17p13.3 located at seventeen-p-thirteen point three 1 YWHAE 17p13.3 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1691 20 194 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     stomach   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemovary  predominantly
     male systemprostate   
     male systemtestis   
    Respiratorylung   moderately
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Timm22 (94.2 pc)
    homolog to murine Timm22 (95.4 pc)
    Homologene
    FAMILY
  • TIM17/TIM22/TIM23 family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • mediating the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane
  • constituting the voltage-activated and signal-gated channel, in the TIM22 complex
  • forming a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps
  • majority of inner membrane protein precursors are synthesized in the cytosol, but precursors with a cleavable presequence are imported by the presequence translocase (TIMM23 complex), while other precursors containing internal targeting signals are imported by the carrier translocase (TIMM22 complex)
  • the carrier translocase (TIMM22 complex) inserts multispanning proteins into the inner membrane
  • TIMM22, TIMM23 import pathways depend on the presence of a membrane potential, which is generated by the activity of the respiratory chain
  • TIMM22 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text protein transport
    PATHWAY
    metabolism
    signaling
  • TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane (Hasson 2010)
  • a component
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B
  • TIMM29 is required for the stability of the TIMM22 complex and functions in the assembly of TIMM22
  • TIMM29 is required for the structural integrity of the TIMM22 complex and for import of substrate proteins by the carrier translocase
  • AGK functions in a kinase-independent manner to maintain the integrity of the TIMM22 complex, where it facilitates the import and assembly of mitochondrial carrier proteins
  • VDAC1 interacts with carrier precursors arriving in the intermembrane space and recruits TIMM22 complexes, thus ensuring an efficient transfer of the precursors to the inner membrane translocase
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIMM22D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS