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FLASH GENE
Symbol IGHA1 contributors: npt - updated : 17-06-2006
HGNC name immunoglobulin heavy constant alpha 1
HGNC id 5478
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three Ig-like (immunoglobulin-like) domains
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin C-type family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • antigen binding
  • major immunoglobulin class in body secretions
  • may serve both to defend against local infection
    • and to prevent access of foreign antigens to the general
    immunologic system
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an homodimer of two D heavy chains bound by an unique disulfide bond
  • each heavy chain is bound to a light chain (kappa or lambda)
  • the N terminus of the heavy chain is bound to a V segment
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS